Of course, the very first thing you will need to pay attention to during a road trip is that you do not get lost as you try to get from "here" to "there," but your second biggest concern will be staying awake during your drive, and one of the biggest aspects of keeping yourself awake will be making sure you are comfortable while driving. There are plenty of different things you will be able to do in your efforts to stay comfortable while driving (and some of the things you can do will depend on the sort of vehicle you are driving), but when you follow these tips, you will be able to take a few solid steps in the right direction!
One of the things that can start to bother you most quickly during a road trip is your back, especially if you are sitting in a seat that causes you to slump back rather than causing you to keep good posture; if you realize that your seat causes you to slump back, put a small pillow (or something similar) behind your back so that you will be sitting more upright - although it might be slightly less comfortable in the short term, this will make a big difference in the long run. Putting constant pressure on the gas pedal is another thing that can make you feel like a long drive is a whole lot of "work"; you can solve this by using cruise control, which will also help you to get better gas mileage. And even though you will probably want to get to your final destination as quickly as possible, you will find that you are actually able to stay more awake when you stop more frequently than just for gas - getting out and walking around a bit every couple hours - which will get you to your destination more quickly in the end, as this will cut down on the naps you need to take. When taking a road trip, the most important thing for you to pay attention to is the safety of both yourself and others, but once you have made sure you are being as safe as possible, your next step will be following these tips to make yourself as comfortable as possible as well!